MYELOID NEOPLASIA Dismal prognostic value of monosomal karyotype in elderly patients with acute myeloid leukemia: a GOELAMS study of 186 patients with unfavorable cytogenetic abnormalities
نویسندگان
چکیده
Aurore Perrot,1 Isabelle Luquet,2 Arnaud Pigneux,3 Francine Mugneret,4 Jacques Delaunay,5 Jean-Luc Harousseau,6 Carole Barin,7 Jean-Yves Cahn,8 Philippe Guardiola,9 Chantal Himberlin,10 Christian Recher,11 Norbert Vey,12 Bruno Lioure,13 Mario Ojeda-Uribe,14 Nathalie Fegueux,15 Christian Berthou,16 Edouard Randriamalala,17 Marie C. Béné,18 Norbert Ifrah,9 and Francis Witz,1 for the GOELAMS (Groupe Ouest-Est des Leucémies Aiguës et Maladies du Sang)
منابع مشابه
Dismal prognostic value of monosomal karyotype in elderly patients with acute myeloid leukemia: a GOELAMS study of 186 patients with unfavorable cytogenetic abnormalities.
The prognosis of acute myeloid leukemia (AML) is very poor in elderly patients, especially in those classically defined as having unfavorable cytogenetics. The recent monosomal karyotype (MK) entity, defined as 2 or more autosomal monosomies or combination of 1 monosomy with structural abnormalities, has been reported to be associated with a worse outcome than the traditional complex karyotype ...
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Cytogenetic abnormalities at diagnosis are important prognostic indicators in acute myeloid leukemia (AML). AML is categorized into 3 risk groups according to cytogenetic abnormalities; favorable, intermediate, and unfavorable. A new cytogenetic risk group called the monosomal karyotype (MK) had been identified in AML in the unfavorable cytogenetic risk group. The MK was reported to be associat...
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In acute myeloid leukemia (AML) the subset with complex karyotype (CK) is traditionally regarded as the worst prognostic group. However, ≥ 3, ≥ 4, or ≥ 5 abnormalities have been variably used for its definition. Recently, monosomal karyotype (MSK) was suggested to indicate an even inferior outcome. We tested which definition fits best to identify the most unfavorable subgroup. After excluding p...
متن کامل[Acute myeloid leukemia].
Acute myeloid leukemia (AML) is a heterogeneous disease that includes subsets with distinct biological, clinical and prognostic features. It has been well established that cytogenetic abnormalities at diagnosis are associated with the biology of the disease and have important prognostic implications. The coexistence of multiple cytogenetic abnormalities designated as complex karyotype (CK) has ...
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